Scleroderma is an autoimmune disease of the connective tissues with ongoing research pointing at environmental factors such as harmful chemicals, organic solvents, and exposure to silica in patients who are genetically predisposed. Scleroderma’s primary feature of the disease is skin thickening that can lead to the scarring, blood vessel anomalies and inflammation. Autoimmune diseases include abnormalities caused by the body’s own defense system attacking its own organs due to a genetic condition or a reaction to antibodies.
Stem cells are the cells responsible for developing an entire human body from a two celled embryo; due to their unlimited divisions and ability to differentiate into different cell lineages. Stem cells have been harnessed by technology to isolate them outside the human body, concentrate them and implant them back into the body. Mesenchymal stem cells are known to have angiogenic, trans differentiation and homing properties which are useful for forming new blood vessels, differentiating into required targeted cells and creating a microenvironment for the faster secretion of immune cells.
Treatment of Scleroderma at Cellebration Life Sciences, Inc.
At Cellebration, we have mastered the technology for isolating the maximum number of viable stem cells from either the autologous sources of your own body or allogeneic with the matched donor to treat various patients with Scleroderma. We are a licensed, private organization with a highly technologically equipped specialized facility under development designed to isolate and enrich the viable cell stems which will be infused into the patient. These cells are administered through one of several methods after a considerable analysis of the patient’s unique history and medical professional’s advice.
- Local Administration: – In this mode, cells are infused directly at the targeted site of injury. Thus, in case of various organs, stem cells are infused directly at the target through catheter-based delivery.
- Sub-Cutaneous Administration: –In this mode, cells are administered in the fat layer of the skin and can help regenerate skin cells, promoting restructuring of skin tissue layers.
- Intravenous Administration: – In this mode, cells are infused into the peripheral veins to expand blood volumes in the system, to ensure that the maximum number of cells are reaching the targeted area.
Infused into the body, these cells can repopulate the damaged parts of the organ. Through paracrine effects, they differentiate into the damaged cells to restore function and continue to regulate the immune system and promote hormonal balance. These cells can regulate the immune system and reduce the impact of autoimmune disorders. One of the important properties of mesenchymal stem cells is to promote proper function which can improve the strength of blood vessels and promote synthesis of new vessels. When infused in the deep layer of the skin, these stem cells are known to promote synthesis of lost fibroblasts, keratinocytes and skin epithelial cells to promote faster restructuring of cells. Thus, with our highly specialized approach, it is now possible to obtain noticeable improvements in patients with Scleroderma, within the symptoms as well as improving functional abilities.
